Hi ed mate..
Just to clarify this for you mate....
Larger notch trowels are used with large format tiles and un-even substrates etc...but you will need to use thick bed adhesives as well...other wise the adhesives cant cope with the bed thickness... wot i mean by thick bed adhesives is these are the type which won,t shrink or slump whilst drying....i.e. BAL PTB...etc etc....there are other makes but this is just an example...
hope this helps...

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BAL PTB (Pourable Thick Bed) Flexible
A highly polymer modified, flexible, rapid-setting, water-resistant, frost-resistant floor tile adhesive, especially suitable for fixing tiles, including fully vitrified and porcelain tiles to low porosity backgrounds and bases. Sulphate-resistant, cement-based, pourable, thick-bed solid-bed floor tile adhesive suitable for fixing ceramic tiles, quarries, natural stone and terrazzo in interior and exterior situations. Its consistency makes it particularly suitable for fixing large tiles and those with profiled backs. Back-buttering is not necessary. Suitable for use on concrete, cement:sand screeds, ceramic/quarry tile/terrazzo/hard natural stone, plywood overlay, vinyl tiles/sheet, mastic asphalt. BS EN 12004 C2F Adhesive